Tandem Mass Tags : Short Communication -nitrosylation Occupancy in the Myocardium with Cysteine-reactive S Measurement Of
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چکیده
Mark J. Kohr, Angel Aponte, Junhui Sun, Marjan Gucek, Charles Steenbergen and Elizabeth Tandem Mass Tags : Short Communication -Nitrosylation Occupancy in the Myocardium With Cysteine-Reactive S Measurement of Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2012 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/CIRCRESAHA.112.27132
منابع مشابه
Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags: short communication.
RATIONALE S-nitrosylation (SNO) is a reversible, thiol-based protein modification that plays an important role in the myocardium by protecting critical cysteine residues from oxidation. However, little is known with regard to the percentage of a given protein that is modified by SNO (ie, SNO occupancy). Current methods allow for the relative quantification of SNO levels, but not for the determi...
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Snitrosylation (SNO) is a reversible, thiolbased modification that can modulate the activity of myocardial proteins, including those involved with Ca-handling and mitochondrial energetics. Additionally, we and others demonstrated that SNO can protect against cysteine oxidation. This is important in the setting of ischemia–reperfusion (IR) injury, in which the burst of reactive oxygen species ge...
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تاریخ انتشار 2012